2019-10-08 09:32:342025-05-11 08:58:00
description
alpha-phosphoglucomutase, required for UDP-glucose synthesis, inhibits [[protein|FtsZ]] ring assembly (indirect effect due to a defect in UDP-glucose synthesis)
alpha-phosphoglucomutase, required for UDP-glucose synthesis, inhibits [[protein|FtsZ]] ring assembly (indirect effect due to a defect in UDP-glucose synthesis), possesses a secondary phosphoglucosamine mutase activity
Gene
Phenotypes of a mutant
cells are bent and distended due to the lack of glucolipids [Pubmed|27684739]
the inactivation of ''[[gene|pgcA]]'' suppresses the poor and filamentous growth of the ''[[gene|whiA]] [[gene|zapA]]'' double mutant [Pubmed|24097947]
inactivation of ''[[gene|pgcA]]'' reduces sporulation efficiency to 0.1% that of wild type cells; smaller and wider mother cells with small forespores [Pubmed|26735940]
resistant to phage SPO1 [pubmed|30811056]
cells are bent and distended due to the lack of glucolipids [Pubmed|27684739]
the inactivation of ''[[gene|pgcA]]'' suppresses the poor and filamentous growth of the ''[[gene|whiA]] [[gene|zapA]]'' double mutant [Pubmed|24097947]
inactivation of ''[[gene|pgcA]]'' reduces sporulation efficiency to 0.1% that of wild type cells; smaller and wider mother cells with small forespores [Pubmed|26735940]
resistant to phage SPO1 [pubmed|30811056]
a [[gene|pgcA]] [[gene|glmR]] double mutant is not viable, this can be suppressed by overexpression of [[protein|GlmM]] [pubmed|31589605]
The protein
Catalyzed reaction/ biological activity
α-D-glucose 1-phosphate --> α-D-glucose 6-phosphate (according to UniProt)
α-D-glucose 1-phosphate --> α-D-glucose 6-phosphate (according to UniProt)
D-glucosamine 6-phosphate --> α-D-glucosamine 1-phosphate (secondary activity, this activity is increased by a G47S mutation) [pubmed|31589605]
The protein
Additional information
PgcA inhibits [[protein|FtsZ]] ring assembly (indirect effect due to a defect in UDP-glucose synthesis)[Pubmed|17662947]
PgcA inhibits [[protein|FtsZ]] ring assembly (indirect effect due to a defect in UDP-glucose synthesis)[Pubmed|17662947]
a PgcA (G47S) variant suppresses the growth defect of a [[gene|glmR]] mutant on gluconeogenic carbon sources in the absence of glucose due to the increased phosphoglucosamine mutase activity [pubmed|31589605]
References
Original publications